MPO and colitis: Furthermore, F. prausnitzii (strain A2-165) or its supernatant has been confirmed to induce a significant reduction in colitis severity by downregulating MPO, pro-inflammatory cytokines, and T-cell levels (Martin et al. 2014), and protecting the intestinal epithelial barrier(Carlsson et al. 2013; Martin et al. 2015) in colitis mouse models.