PRMT5 and lung neuroendocrine neoplasm: For example, nuclear overexpression of the protein arginine methyltransferase-5 (PRMT5), which is a chromatin-modifying enzyme, was reported to be more frequent in pulmonary carcinoids than in neuroendocrine carcinomas, suggesting different epigenetic regulatory mechanisms controlling oncogenesis in carcinoids as compared with high-grade pulmonary neuroendocrine neoplasms [56].