In our cohort of 20 prostate cancer patients across a variety of miTNM stages undergoing [68Ga]Ga-PSMA-11 PET, only two small nodal lesions (short-axis diameter of ≤ 4 mm) were missed (Figs. 1 und 2) leading to miTNM downstaging in one case. The gene discussed is FOLH1; the disease is Familial prostate cancer.