Previous studies have shown that hCCL15 binds the cell surface receptor CCR1 and may contribute to the severity of asthma and airflow limitation by affecting airway smooth muscle cells.36 Furthermore, we provide evidence that mCCL6 activates CCR1 downstream of the Gαi protein and related phosphorylated signaling proteins to activate HSCs and promote HSC differentiation, providing convincing evidence of the CCL6-CCR1 axis. Here, CCR1 is linked to asthma.