Previously we have screened the gene expression profile in RAW264.7 macrophages after infection with the RNA virus vesicular stomatitis virus (VSV) and the DNA virus herpes simplex virus 1 (HSV-1).25 Among the Trim genes, we noted that Trim41 mRNA was downregulated by virus infection (GEO accession number GSE72077). The gene discussed is TRAT1; the disease is infection.