TRIM41 and psoriasis: Pathogenic nucleic acids derived from both pathogens and hosts are critical stimulator of innate PRR signaling and have been closely linked to inflammatory, autoimmune and tumorous diseases.1–3 Data derived from gene databases, especially data for upregulated Trim41 mRNA expression in skin samples with lesions derived from psoriasis patients (GEO accession number GSE13355), indicate a potential linkage between Trim41 and inflammatory diseases.