Although CX3CR1, CD18, and Iba1 are expressed on ramified microglial cells, the presence of CD163-positive and CD14-positive mononuclear phagocytes in AMD demonstrates an activation of microglial cells and/or the recruitment of monocyte-derived macrophages, supporting the notion that AMD may be an inflammatory disease. The gene discussed is ITGB2; the disease is age-related macular degeneration.