PGF and diabetes mellitus: Furthermore, angiogenesis in ischemic retinas and laser-injured choroids, as well as diabetes-induced retinal cell death, capillary degeneration, pericyte loss, and BRB breakdown were alleviated in Pgf KO mice or by pharmacologically inhibiting PlGF activity (Apicella et al., 2018; Carmeliet et al., 2001; Crespo-Garcia et al., 2017; Huang et al., 2015; Rakic et al., 2003).