However, follow up of disease activity over 3-7 years (mean=4.9 years) revealed that the baseline ApoB:ApoA1 ratio correlated positively with average longitudinal SLEDAI-2000 score and negatively with longitudinal Lupus Low Disease Activity State (LLDAS) (Fig. 6c-d). Here, APOB is linked to systemic lupus erythematosus.