In order to verify this, metabolites known to have altered expression in adult SLE patients with established pre-clinical carotid and femoral artery atherosclerotic plaque were examined [35]: namely elevated ratios of monounsaturated:total fatty acids and triglycerides:phosphoglycerides, elevated glycoprotein acetyl levels and reduced ratios of omega-6:total fatty acids. The gene discussed is ART4; the disease is systemic lupus erythematosus.