In opposite to these, Shi et al. highlighted the reversal of the growth inhibition in human gastric cancer cells caused by miR-218 regulated TFF1. Likewise, overexpression of Hs_miR-218_3p in the malignant group might negatively regulate TFF1 in an Erk1/2-dependent manner and promote malignancy as suggested [44]. The gene discussed is MAPK3; the disease is gastric cancer.