TGFB1 and cancer: We report that EGR1 is also upstream of E2-induced TGFβ1 transcription in primary human dermal fibroblasts, which is not surprising as EGR1 binds to and activates the TGFβ1 promoter [31] and exogenous expression of EGR1 in the cancer cell line HT1080 led to increased secretion of TGFβ1 [51].