Evaluation of long-term effects of LA showed a significant reduction of sP-selectin in HeFH (40% cases, average yearly reduction 9.92 ng/mL) and a significant decrease of CD40L and hsCRP in HoFH patients (50% and 75% of patients, with average yearly reduction 477 pg/mL and 0.62 mg/L, respectively) (Table 3). This evidence concerns the gene CD40LG and homozygous familial hypercholesterolemia.