Also, in an experimental mouse model of atherosclerosis with hypercholesterolemia, soluble endoglin levels were increased before the formation of visible atherosclerosis in the aorta and during the formation of advanced lesions [21–23], suggesting the association of soluble endoglin with hypercholesterolemia and endothelial dysfunction/atherogenesis. The gene discussed is ENG; the disease is familial hypercholesterolemia.