HeFH, heterozygous familial hypercholesterolemia; HoFH, homozygous familial hypercholesterolemia; TC, total cholesterol; LDLC, low density lipoprotein cholesterol; HDLC, high density lipoprotein cholesterol; apoB, apoprotein B; CD40L, CD40 ligand; hsCRP, high sensitivity C-reactive protein; MCP-1, monocyte chemoattractant protein-1; sP-selectin, soluble plasma selectin. The gene discussed is CD40LG; the disease is familial hypercholesterolemia.