HeFH, heterozygous Familial hypercholesterolemia; HoFH, homozygous Familial hypercholesterolemia; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; apoB, apoprotein B; CD40L, CD40 ligand; hsCRP, high sensitivity C-reactive protein; MCP-1, monocyte chemoattractant protein-1; sP-selectin, soluble plasma selectin. The gene discussed is CCL2; the disease is familial hypercholesterolemia.