Exosomal has-miR-423 probably involves in the process of MSI by regulating SLC39A10 and FOXQ1. Moreover, exosomal hsa-miR-139 could target SLC39A10, KIAA1549, FUTI, and LZTS1 to exert several biological functions in CRC development. Here, LZTS1 is linked to colorectal carcinoma.