As shown in Fig. 4c, the target genes of the differentially expressed exosomal miRNAs were mainly enriched in embryonic organ development and Ras protein signal transduction in GO-BP, presynapse and transcription factor complex in GO-CC, DNA-binding transcription activator activity and DNA-binding transcription activator activity, RNA polymerase II-specific in GO-MF, and proteoglycans in cancer, PI3k-Akt and MAPK signaling pathways in KEGG pathway analysis. This evidence concerns the gene AKT1 and cancer.