Interestingly, although miR-144 levels were reduced in T1DM diabetic mice model and in HG conditions in cultured cardiomyocytes, the administration of miR-144 mimic reduced the expression of Nrf2 proteins and augmented ROS formation, whereas miR-144 inhibitor enhanced Nrf2 expression and decreased ROS generation. Here, NFE2L2 is linked to type 1 diabetes mellitus.