The above-mentioned studies indicate that the influence of LncRNAs on CASP-1, NLRP3, SIRT1 and TGF-β pathways presents as a new significant pathophysiology mechanism of cardiac remodeling in DCM and stands as a possible future therapeutic target (Fig. 2) (Table 2). The gene discussed is SIRT1; the disease is familial dilated cardiomyopathy.