TNF and cancer: The meta-analysis comparing the concentration of SC in OC patients versus healthy controls showed a significant increase in the level of IL-8 (standardized mean difference (SMD) = 1.77; 95% CI 0.79 to 1.55), IL-6 (SMD = 2.08; 95% CI 1.33 to 2.84), TNF-α (SMD = 2.04; 95% CI 0.47 to 3.61), IL-1β (SMD = 0.78; 95% CI 0.44 to 1.13), and IL-10 (SMD = 0.46; 95% CI 0.05 to 0.86) in the cancer group.