However, when comparing IL-8 salivary concentration in OPMD patients against healthy controls, it was not significant with a bordering value (SMD = 0.20; 95% CI 0.00 to 0.40), and heterogeneity was very low (I2 = 0%, p = 0.53) (Fig. 4a). The gene discussed is CXCL8; the disease is oculopharyngeal muscular dystrophy.