XIST is another potential biomarker of osteosarcoma which has been reported to modulate osteosarcoma proliferation and invasion through miR-320b/RAP2B [87], miR-193a-3p/RSF1 [88], miR-21-5p/PDCD4 [79], and miR-195-5p/YAP axis [78]. This evidence concerns the gene PDCD4 and osteosarcoma.