In this study, the underexpression of miR-126-3p, a post-transcriptional regulator of genes involved in angiogenesis (VEFG) and cell proliferation (SLC7A5), was found to be associated with CCA and may be potentiated by alcoholism, SAH, DM, and smoking; smoking was also found to be an independent risk factor for CCA. The gene discussed is SLC7A5; the disease is cholangiocarcinoma.