Moreover, 15% of LCNEC tumors showed genetic changes in P13K/AKT/mTOR pathway; it was also observed that LCNEC might have activating mutations in receptor tyrosine kinase genes such as EGFR, KIT, ERBB2 (Umemura et al., 2014, Miyoshi et al., 2017). The gene discussed is NTRK1; the disease is large cell neuroendocrine carcinoma.