LOX expression is found to be upregulated by HIF-1α and is required for hypoxia-induced metastasis in human breast and head and neck tumors.(Cano et al., 2012) Secreted LOX and hypoxia are relevant to metastasis and premetastatic niche formation in breast cancer (Canesin et al., 2015). This evidence concerns the gene LOX and breast carcinoma.