Also, structural studies show that OM binds to stabilize myosin in a pre-powerstroke state in which the LCD is primed to transition into the powerstroke, which results in an increase in the number of myosins that are actin-attached in a force-producing state (18) and thus, making OM a potential activator candidate for therapeutics of heart failure. The gene discussed is MYH14; the disease is heart failure.