In summary, by integrating comprehensive maps of genome-wide gene expression in the human brain and neuroanatomic data from the largest existing sample of 22q11DS individuals with molecularly confirmed A-D deletions, we prioritized DGCR8 and AIFM3 as potential contributors to cortical SA alterations in 22q11DS, and P2RX6 as a potential contributor to CT alterations. This evidence concerns the gene P2RX6 and 22q11.2 deletion syndrome.