Our finding that systematic investigation of 22q11.2 genes prioritized relatively understudied genes (i.e., AIFM3 and P2RX6) and a gene previously hypothesized to play a key role in 22q11.2 phenotypes (i.e., DGCR8), provides important opportunities to pursue novel mechanistic hypotheses in 22q11DS. Here, AIFM3 is linked to 22q11.2 deletion syndrome.