Finally, our exploratory analysis of down-regulated miRNA gene targets due to DGCR8 hemizygosity was based on findings in postnatal cortical samples from 22q11.2- and DGCR8-deficient mouse models; it would be ideal to examine down-regulated miRNAs in cortex derived directly from individuals with 22q11DS or with DGCR8-specific hemizygous mutations, particularly during early corticogenesis. Here, DGCR8 is linked to 22q11.2 deletion syndrome.