Given the prominent gene regulatory role of DGCR8 via microRNA (miRNA) biogenesis, to follow up on spatial convergence results between regional expression of DGCR8 and 22q11DS cortical ΔSA severity, we characterized the gene targets of miRNAs previously suggested to be down-regulated in the cortex due to DGCR8 deficiency. The gene discussed is DGCR8; the disease is 22q11.2 deletion syndrome.