DGCR8 and 22q11.2 deletion syndrome: Spatial correlation analyses comparing the expression patterns of 22q11.2 genes to ΔSA severity in 22q11DS revealed a significant positive correlation between regional expression of DGCR8 and regional ΔSA severity, Pearson r = 0.53, and PAHBA = 0.006 (Fig. 1A–C; Table 2).