Our pervious study has proved that, resveratrol suppressed the expression of sirt1 and thereby decreased the expression of thrombosis-related markers P-selectin, P-selectin glycoprotein ligand 1 (PSGL-1), and Von Willebrand factor (VWF) in HUVEC [29], We therefore used SAMP-1 mice to establish DVT model and to further investigated the effect of Srit1 on DVT. This evidence concerns the gene SIRT1 and deep vein thrombosis.