MAPT and Alzheimer disease: Recently, Ramusino and colleagues compared the relative incremental diagnostic value of amyloid-PET and CSF (Aβ42, p-tau, t-tau), showing that amyloid-PET induces greater changes in the diagnosis of AD patients and an overall increase of diagnostic confidence when performed both as the first investigation and even after CSF, possibly because of the higher negative predictive value of amyloid-PET [9].