TTN and familial dilated cardiomyopathy: At transcript level, three of the four top KEGG pathways in our RNAseq dataset—“Ribosome”, “Oxidative Phosphorylation” and “Proteasome “—were also in the top four KEGG pathways to be found enriched in human cardiac biopsies from DCM patients with titin truncating variants, when compared to samples from DCM patients without titin truncating variants [56], suggesting that our titin missense model shares some molecular similarities with DCM caused by titin truncating variants, at least at the transcriptome level.