VCAM1 and neurodegenerative disease: Due to its ubiquitous presence in neurological disease, we sought to target neuroinflammation in this screen in particular because together, endothelia and pericytes are the major mediators of leucocyte extravasation during neurodegenerative diseases, particularly in AD and MS, through CCL2-directed chemotaxis and ICAM-1 and VCAM-1-mediated adhesion55,72–74.