SRF and dilated cardiomyopathy: Interestingly, heart defects in CAP2 mutant mice including dilated cardiomyopathy and impaired cardiac conductance were partially restored upon pharmacological inhibition of MRTF-SRF activity, demonstrating that CAP2-dependent regulation of the MRTF-SRF pathway is physiologically relevant and that its dysregulation due to CAP2 inactivation contributes to pathological conditions19.