Several osteoarthritis GWAS signals were found to co-localise with eQTLs in only 1 or 2 of 53 tissues (e.g. ALDH1A2: ovary and tibial artery, SMAD3: skeletal muscle; SLC44A2: adrenal gland), without clear transferability of results to disease-relevant tissue. This evidence concerns the gene SMAD3 and osteoarthritis.