In consistent, the glucose uptake and the lactate production were also reduced when HIFAL expression was knocked down by LNAs in breast cancer cells under hypoxia (Supplementary Fig. 6m–p), whereas enforced expression of HIFAL increased the glucose uptake and the lactate production in these cells (Supplementary Fig. 6q–r). Here, ENSG00000258667 is linked to breast carcinoma.