HIF1A and neoplasm: Also, our above data showed that targeting HIFAL abrogated the transcription of HIF-1 target genes upon prolonged hypoxic treatment (Fig. 1g–j), we sought to test whether simultaneous inhibition of HIF-1α and HIFAL would exert synergistic effects to prevent tumor growth and thus employed an LNA-based anti-sense oligonucleotide11 to inhibit the expression of HIF-1α mRNA as reported in previous phase I clinical trial.