These observations were further consolidated by the in situ hybridization for HIFAL and immunohistochemistry for PKM2 or PHD3 in breast cancer tissues, which showed co-localization of HIFAL with PKM2 and PHD3 in the nuclei of cancer cells (Fig. 3i and Supplementary Fig. 3l, m). The gene discussed is ENSG00000258667; the disease is breast cancer.