HIF-1 target genes, including the genes coding glycolytic receptors and enzymes, including glucose transporter GLUT1, hexokinase II (HKII), lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1 (PDK1)5–8, switch the tumor cells from oxidative to anaerobic glycolysis in order to adapt to tumor hypoxic condition5,9. Here, HK2 is linked to neoplasm.