Other prosurvival members of the BCL-2 family have been implicated to varying degrees in the pathogenesis of other hematological malignancies including acute myeloid leukemia (AML)9,10, chronic myeloid leukemia (CML)11–15, multiple myeloma16, diffuse large B-cell lymphoma17, and acute lymphoblastic leukemia (ALL)18. The gene discussed is BCL2; the disease is acute lymphoblastic leukemia.