The serine/threonine-specific protein kinase Akt/Protein kinase B, a downstream target of BCR-ABL, is constitutively active in CP-CML and BP-CML cells; Akt inhibits a conformational change in BAX required for translocation to the mitochondrial membrane, thus hindering MOMP in response to cellular stress36,37. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.