At present, most of the studies on TFE3 and cancer focus on Xp11.2 translocation renal cell carcinoma (tRCC) but not ccRCC, a special type of RCC characterized by gene fusions involving TFE3 or TFEB. This evidence concerns the gene TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.