To further establish the regulatory effect of LRP6 on YAP expression in colon cancer cells, three siRNAs with different sequences (siLRP6, siLRP6#1, and siLRP6#UTR) were administered to SW1116 cells, whereas siLRP6#UTR targeted the 5′-untranslated region (5′-UTR) of LRP6 mRNA. The gene discussed is LRP6; the disease is colonic neoplasm.