SPPL2C and Alzheimer disease: The novel AD-associated SNP rs56201815 (meta-analysis p = 2.35E−12) is a synonymous variant in ERN1. rs12373123, a missense variant of SPPL2C (Table 1), is located in a large LD block spanning the MAPT region and it is in complete LD with multiple synonymous, nonsense, or missense variants in CRHR1 and MAPT. In APOE ε4 non-carriers, the hazards of AD were consistently lower in the carriers of the minor allele of rs12373123 after age 70 (Fig. 2D).