Its significance in APOE ε4 non-carriers was higher, suggesting that the effects of TREM2 on AD were independent of APOE. Besides, multiple genes in the MAPT region including MAPT, KANSL1, NSF, and SPPL2C were associated with the risk of AD in both analyses (Fig. S5A, B). This evidence concerns the gene SPPL2C and Alzheimer disease.