Twenty-seven (16 males) rs56201815-G carriers in ADSP (a total of 29 carriers in which two were excluded from the analyses because they transformed from control to mild cognitive impairment (MCI) during the follow-up in ADSP, and their AD status was unknown) were sampled from 11 cohorts including ACT, ADC, CHAP, MAYO, MIA, MIR, ROSMAP, VAN, ERF, FHS, and RS (Table 2). Here, SYNPO2L is linked to Alzheimer disease.