This SNP is located in an LD block spanning >400 kb, and is in high LD with a large number of SNPs including multiple missense variants in MAPT, SPPL2C, CRHR1, and KANSL1. Previous GWAS show that rs12373123 and two nearby missense SNPs (rs12185268 and rs12373124) in complete LD with rs12373123 exhibit pleiotropic associations with numerous diseases and traits including intracranial volume57, corticobasal degeneration58, Parkinson’s disease (PD)59–62, primary biliary cirrhosis63, red blood cell count64, and androgenetic alopecia65. The gene discussed is SPPL2C; the disease is Parkinson disease.