APOE and Alzheimer disease: Our gene-set analysis using FUMA48 based on the summary statistics from the exome-wide association analysis conditional on APOE ε4 revealed that Gene Ontology (GO) gene sets related to the regulation of astrocytes, amyloid-beta, endoplasmic reticulum (ER) stress, and unfolded protein response (UPR) were among the top enriched gene sets associated with AD (Fig. 5A).