In the brain, many neurodegenerative diseases are associated with neuronal protein aggregate accumulation, such as α-synuclein (Parkinson’s disease, Lewy Body dementia), TDP-43 (motor neuron disease, fronto-temporal dementia (FTD)) and Tau (Alzheimer’s disease, FTD), and both genetics, molecular pathology and animal studies point to defects in proteostasis in patho-progression12–14. The gene discussed is MAPT; the disease is frontotemporal dementia.