CREBBP and nervous system disorder: Defective CBP has been found in human diseases, including Rubinstein–Taybi syndrome, tumors (e.g., leukemia, a variety of translocations of CBP genes have been characterized so far), and neurological disorders, such as Huntington’s disease8, Alzheimer’s disease9, polyglutamine diseases10, and spinal and bulbar muscular atrophy11.