Defective CBP has been found in human diseases, including Rubinstein–Taybi syndrome, tumors (e.g., leukemia, a variety of translocations of CBP genes have been characterized so far), and neurological disorders, such as Huntington’s disease8, Alzheimer’s disease9, polyglutamine diseases10, and spinal and bulbar muscular atrophy11. This evidence concerns the gene CREBBP and leukemia.