Interestingly, 15 patients with life-threatening COVID-19 not only had auto-Abs against IFN-α2 and/or IFN-ω, but also had auto-Abs against other cytokines (IFN-γ, GMCSF, IL-6, IL-10, IL-12p70, IL-22, IL-17A, IL-17F, and/or TNFβ). The gene discussed is IFNA2; the disease is COVID-19.