Yoon JH et al. reported that lncRNA LUCAT1 in esophageal squamous cell carcinoma (ESCC) maintained the expression stability of DNMT1 by regulating methyltransferase to improve the level of DNA methylation, thereby inhibiting the expression of a series of tumor-suppressor genes and promoting the progression and metastasis of ESCC17. Here, DNMT1 is linked to esophageal squamous cell carcinoma.