The following experimental results further indicated that lnc-LALC could EMT phenotype in CRC cells mediated by LZTS1.In all, we could get the conclusion that Long non-coding RNA Lnc-LALC facilitates CRC liver metastasis through EMT via epigenetically silencing of LZTS1 via regulating methylation of LZTS1 promoters mediated by DNMTs. The gene discussed is LZTS1; the disease is colorectal carcinoma.