On the basis of the specifically correlation between LINC00922 and LZTS1 founded in our research, we named LINC00922 as LZTS1 associated LncRNA in CRC(Lnc-LALC).We found that Lnc-LALC could enhance the CRC cells metastasis ability in vitro and vivo through inhibiting the expression of LZTS1. Furthermore, the precise mechanisms showed that lnc-LALC could recruit DNA methyltransferases (DNMTs) to the LZTS1 promoter by combining with Enhancer of zeste homolog 2 (EZH2). This evidence concerns the gene LZTS1 and colorectal carcinoma.