MiR-128-3p is able to suppress CYP2C9 expression/production in human hepatic cells by specifically targeting the 3’-UTR of CYP2C9 mRNA molecules.499 The expression of CYP2C9 is also reported to be directly and negatively regulated by miR-130b.500 The translation efficiency (protein/mRNA ratio) for CYP2C8 was significantly inhibited by miR-103 and miR-107, which also targeted CYP2C9 and CYP2C19 to a lesser degree than CYP2C8 in the human Liver.501 Taken together, miRNAs-mediated regulation of CYP epoxygenases may contribute to cancer treatment. This evidence concerns the gene CYP2C9 and cancer.