INS and diabetes mellitus: Also, in this situation, the cardiac-specific overexpression of CYP2J2 has beneficial effects on DCM and insulin resistance in high-fat diet-fed, low-dose streptozotocin-treated mice.181 In particular, the overexpression of CYP2J2 resulted in the maintenance of contractile activity, improved heart-specific glucose uptake, and insulin sensitivity, and attenuated the hypertrophy associated with diabetes.