CYP3A4 and hepatocellular carcinoma: Knockdown of CYP3A5 and -2C8, both of which exhibit homology with CYP3A4, inhibited the proliferation of the MCF7, T47D, and MDA-MB-231 lines to varying degrees.391 Also, overexpression of CYP3A4 promoted the cell growth and cell cycle progression from the G1 to the S phase in a human hepatoma cell line, which was attenuated by a putative EET receptor antagonist, 14,15-EEZE and a PI3K inhibitor.392 These results suggest that CYP3A4 activity can accelerate tumor progression, which is independent of the activation of carcinogens and metabolism of anti-cancer drugs.