In addition, carcinoma cells overexpressing CYP2J2 generated tumors at a faster rate and resulted in larger tumors than those generated from control carcinoma cells in vivo xenograft tumor model.261 Similarly, EETs promoted proliferation and increased the number of cells in the S/G2-M phase in a dose- and time-dependent manner in four tumor cell lines. This evidence concerns the gene CYP2J2 and carcinoma.