Such data demonstrate that the EP2 receptor mediates arterial dilatation, salt-sensitive hypertension, and also plays an essential part in female fertility.115 However, PGI2-IP and TXA2-TP system has been reported to be resistant to renovascular hypertension or Ang II-induced hypertension.108,116 In addition, the endothelial expression of PGD synthases, which is responsible for PGD2 synthesis from PGH2, can be upregulated in response to higher shear stress in the circulation.117 Genetic deletion of lipocalin-type PGD synthases in mice triggers hypertension and thrombogenesis.92 The gene discussed is AGT; the disease is hypertensive disorder.