PPIG and obesity due to melanocortin 4 receptor deficiency: CYP-derived EETs and 20-HETE induce insulin secretion and protect pancreatic islet cells from apoptosis.21,440 Diabetes and obesity are associated with an enhanced expression of the sEH, and genetic deletion of the sEH ensues an improved insulin sensitivity and an anti-apoptotic effect on pancreas islet cells in the murine diabetes model.441 Recent data suggest that CYP enzymes and EETs are involved in the homeostasis of metabolic diseases, including obesity and diabetes.442,443 Previous study has also shown that sEH is expressed in adipose tissue,444 hepatocytes,445, and pancreatic islets.