PPIG and hepatocellular carcinoma: Emerging evidence has demonstrated that CYP-derived EETs regulates multiple cellular processes of carcinogenesis and progression, including cell proliferation, survival, angiogenesis, invasion, and metastasis.23,311,312 CYP enzymes, such as CYP2J2 are highly expressed in various human carcinoma cell lines (including LS-174, ScaBER, SiHa, U251, A549, Tca-8113, Ncl-H446, and HepG2) and human tumors (including esophageal adenocarcinoma, pulmonary carcinoma, breast carcinoma, stomach carcinoma, liver carcinoma, and colon adenocarcinoma).