COX-2, on the other hands, more frequently feeds PGG2/H2 to the prostaglandin I synthase (PGIS) and the microsomal (m) PGES isozymes, both of which are often coinduced with COX-2 by cytokines and tumor promoters.31–34 The profile of prostanoid production is determined by the differential expression of these enzymes within cells present at sites of inflammation. The gene discussed is PTGS2; the disease is neoplasm.