Hypoxia stimulates the expression of a series of CYP enzymes in endothelial cells including CYP2C8 and CYP2C9 to increase EET formation.220,233 Importantly, the same stimulus suppresses the expression of the sEH, at least in the mouse liver and a human hepatoma cell line234 to further increase EET levels. The gene discussed is PPIG; the disease is hepatocellular carcinoma.