ALOX5 and prostate carcinoma: For example, there are numerous reports of increased 5-LOX expression in cancer cells, e.g., 5-LOX and 5-LOX activating protein (FLAP) was universally expressed in epithelial cancer cell lines,288 and 5-LOX was elevated in human pancreatic cancer cells289 as well as in malignant tissue from patients with prostate carcinoma.