The latter was reported to improve insulin sensitivity and may prevent the development of DM.450 For instance, LXA4 inhibits IL-6, TNFα, and ROS production thus hampers obesity-associated inflammation and has an anti-diabetic effect.451–453 LXs are endogenously produced eicosanoids with a spectrum of anti-inflammatory, proresolution, and antifibrotic bioactions. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.