These results indicate that PGE2 produced endogenously during ischemia or reperfusion can protect the heart from injury.103 Less is known about EP3 receptors but several studies indicate that EP3 agonists also protect the heart from injury by facilitating the opening of KATP channel, also the cardio-äspecific overexpression of EP3 attenuated myocardial ischemia-reperfusion injury.104–106. The gene discussed is PTGER3; the disease is ischemia.