20-HETE has long been implicated in the proliferation of tumor cells and endothelial cells, often invoking the participation of growth factors, such as VEGF, epidermal growth factor (EGF), fibroblast growth factor (FGF), or platelet-derived growth factor (PDGF).358 Modulation of the CYP4:20-HETE pathway has very pronounced effects on tumor size in animal models of the brain, kidney, and breast cancer. This evidence concerns the gene VEGFA and neoplasm.