TNF and carcinoma: In 2005, our laboratory explored the potential roles of CYP2J2 and its active products EETs on the neoplastic phenotype of carcinoma cells for the first time.261 Overexpression of CYP2J2 or addition of EETs to cultured carcinoma cell lines in vitro markedly accelerated proliferation, cell counts, cell cycle, and protected carcinoma cells from apoptosis induced by TNF-α.