NLRP3 and Hyperglycemia: Hyperglycemia induces the production of pro-inflammatory mediators by PMNs, gives rise to oxygen radical formation, hampers PMN chemotaxis, and supports the adhesion of PMNs to the vasculature in diabetic mice.78,430 In addition, free fatty acids activate the NLRP3-ASC inflammasome, and a disruption of the associated Nod-like receptors (NLRs) protects against insulin resistance and hyperglycemia in obesity.431 Glucose and lipid metabolism share various metabolic pathways.