It is therefore not surprising that 12/15-LOX knockout mice demonstrate a partial resistance to diabetes development.433,435–437 Similarly, LTs, produced by 5-LOX and 12-LOX-derived HETEs, inhibits pancreatic insulin secretion, and the genetic disruption or pharmacological inhibition of these LOXs protects against pancreatic islet cell destruction in diabetic mice.438 LTB4 has been found to be essential for the recruitment and activation of adipose tissue B2 lymphocytes, which contribute to the establishment of insulin resistance following a high-fat diet.439. This evidence concerns the gene INS and diabetes mellitus.