PPIG and ischemia reperfusion injury: For example, EETs were found to be a slightly stronger pro-angiogenic factor than other in vivo and in vitro.73,74 CYP-derived EETs are probably best studied with respect to their hyperpolarizing properties as EETs are endothelium-derived hyperpolarizing factors (EDHF) in some organs (particularly in the heart) and thus contribute to the regulation of vascular function.19 It is also now clear that CYP-derived EETs also protect the heart against acute ischemia-reperfusion injury and chronic non-ischemic cardiomyopathy and hypertension.