EPHX2 and ischemia: Reduced oxygen levels lead to a wide range of consequences for heart activity and morphology that are detrimental to proper function and homeostasis.140 Overall, CYP-derived EETs in the heart has been shown to improve the outcomes of ischemia and/or ischemia/reperfusion injuries.141,142 This is relevant inasmuch as the expression of many CYP enzymes is increased by hypoxia,143 while that of the sEH is decreased144—conditions that would favor EET stability and bioavailability.