CYP2J2 and Hypertension: For example, two intronic CYP2J2 SNPs (rs10889160 and rs11572325) were associated with an increased risk of MI.324 In addition, the most common variant (CYP2J2*7) with the frequency of 1.1–1.2% in a Russian, 2.6% in Chinese, and 11–17% in Africans increased the risk of hypertension and MI,195,325 is linked with a diminished capacity to synthesize EETs.326 Tumor development and cardiovascular benefits are often contradictory when assessing CYP2J2-EET functions.