EPHX2 and coronary artery disorder: Plasma concentrations of stable EET metabolites were significantly lower in individuals with the G-50T SNP.195 In addition, the presence of the CYP2J2*7 allele in an African-American population was associated with a significantly lower risk of incident CAD, while an increased risk of CAD along with lower plasma EET levels were observed in a Caucasian population195 Interestingly, EPHX2 polymorphisms have been linked to risk for coronary artery calcification and disease in young adults.197