We analyzed the TCGA public database of 263 STS samples (cBioPortal.org) to identify the potential role of HDACs in sarcoma and observed an association between higher expression of class I HDACs, including HDAC1, HDAC2 and HDAC3 with shorter overall survival (p<0.001) (figure 2A). The gene discussed is HDAC3; the disease is sarcoma.