In this pathway, ACE2 performs an important regulatory role, converting angiotensin II to angiotensin 1–7, which causes vasodilatation and has antiinflammatory effect, unlike activation of angiotensin receptor, which will lead to vasoconstriction, higher blood pressure, and inflammation (potentially ARDS) (10–13). The gene discussed is ACE2; the disease is acute respiratory distress syndrome.