SGLT2 inhibitors cause osmotic diuresis due to glucosuria and natriuresis, although the degree of diuresis and its composition (ie, the amount of natriuresis compared with aquaresis) remains to be established.18 Indeed, in the context of co-administration of loop diuretic therapies, the contribution of osmotic diuresis towards improved heart failure outcomes remains unclear. Here, SLC5A2 is linked to heart failure.