Subsequently, we evaluated the ecto-GPR37 content in the CSF from NC and AD patients using the GPR37 NL-based ELISA assay, and found no significant difference between the NC (203 ± 42 pg/ml) and AD (304 ± 61 pg/ml) subjects (P = 0.1266; Fig. 5c). The gene discussed is GPR37; the disease is Alzheimer disease.