The detection of genomic instability in progeny of cells cocultured with cancer cells for only 5 h suggests that in addition to modulation of Cav-1 and other markers and/or perturbations in the redox environment detected at 120 h of coculture, other mechanisms are altered in stromal cells following rather short coculture times with cancer cells and contribute to genomic instability. Here, CAV1 is linked to cancer.