SMYD3 and esophageal squamous cell carcinoma: EZR-AS1 recruits SMYD3 to SMYD3 binding sites in the GC-rich region downstream of the EZR promoter, leading to SMYD3-targeted H3K4 tri-methylation, while the SMYD3-EZR AS1 interaction that enhances EZR transcription and expression to increase migration of ESCC cells [77].