To investigate the role of SMYD3 in colorectal cancer (CRC) and hepatocellular carcinoma (HCC) formation, Sarris et al. generated a mouse model of Smyd-deficient, overexpressing, or wild-type mice (C57BL/6) and exposed them to diethylnitrosamine (DEN) or 1,2-dimethylhydrazine/dextran sodium sulfate (DMH/DSS), chemicals known to induce CRC and HCC and in wild-type mice of this strain [36]. The gene discussed is SMYD3; the disease is hepatocellular carcinoma.