SMYD3 and colonic neoplasm: Furthermore, mRNA levels of transcription regulators (Snai1, Snai2, Twist, Zeb1, and SOX4) and EMT marker genes (Fn1, Vimentin, Timp1, Mmp2, Mmp7, Mmp9, Mmp14) were significantly increased in liver/colon tumors of wild-type mice when compared to Smyd3-deficient mice [36].