Consistently with the two studies above, Wang et al. provided further evidence corroborating the role of SMYD3 in HCC cellular proliferation and invasion by demonstrating that SMYD3 enhanced the transcription of cyclin-dependent kinase 2 (CDK2) and matrix metalloproteinase-2 (MMP2) through tri-methylation of H3K4 at the corresponding promoter sites [2]. The gene discussed is CDK2; the disease is hepatocellular carcinoma.