CCND2 and Familial prostate cancer: While no changes in H3K4 and H3K27 methylation marks were seen, there was a significant decrease in the H4K20me3 repressive mark in sh-SMYD3 prostate cancer cells, providing further evidence that SMYD3 expression may repress CCND2 expression via H4K20 tri-methylation in prostate cancer [61].