As p53 had previously been shown to play an important role in malignant gliomas [88], the authors examined whether SMYD3 affected p53 in human glioma cell lines and showed that SMYD3 depletion increased p53 protein levels, and conversely, SMYD3 overexpression decreased p53 and protein levels [87]. The gene discussed is SMYD3; the disease is central nervous system cancer.