PYCARD and neoplasm: In our previous work, we have shown that the methylation status of two genes, ASC/TMS1/PYCARD (apoptosis-associated speck-like protein containing a caspase recruitment domain) and MyD88 (Myeloid differentiation primary response protein 88), could be considered as a promising biomarker in non-small cell lung cancer (NSCLC) in distinguishing healthy from tumor tissue [5].