ALOX5 and neoplasm: Apart from directly targeting the tumor cells with CD1d positive, recent literature on the mice model demonstrated that NKT cells could restrict the tumor evolution of PDAC indirectly by suppressing the pro-immunosuppression role of macrophages through prostaglandin E synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX) [27].