Our transgenic mouse overexpressing Htra1 through a ubiquitous CAG promoter (CAG-Htra1 Tg mouse) showed a CNV-like phenotype after 12 months (17) while others have, using RPE-specific promoters, demonstrated a polypoidal choroidal vasculopathy (PCV)-like phenotype but not CNV (18, 19). This evidence concerns the gene HTRA1 and Polypoidal choroidal vasculopathy.