Previous work from our laboratory reported that global genetic ablation of iPLA2γ resulted in multicomponent abnormal phenotypes which included compromised mitochondrial ultrastructure and function, insulin hypersensitivity, the inability to gain weight during HF feeding, impaired skeletal muscular respiration and strength, and lower triacylglycerol content in adipose tissue (20). Here, PNPLA8 is linked to hydrops fetalis.