GPR31 and myocardial ischemia: A number of previous studies have reported multiple detrimental effects of LOX-generated HETE signaling which include induction of oxidative stress during cardiac ischemia/reperfusion and activation of proinflammatory effects via p38MAPK for immune responses by stimulation of cytokine and inflammatory gene expression presumably through activation of G protein-coupled receptor 31 (10, 27, 28, 29, 30).