Our recent study has revealed that SND1, as an oncogene, is able to hijack nascent MHC-I heavy chain in tumor cells, thereby impairing the proper assembling of HC and sensitizing tumor cells to a diminished immune surveillance with abolished antigen presentation to cytotoxic CD8+ T cells[23], which is the initial report that links SND1 to immune system. This evidence concerns the gene SND1 and neoplasm.