CD4 and infection: Meanwhile, we also examined the proportion of other immune cells and found that there was no difference between WT and SND1-/- mice under naive condition in CD4+T, CD8+T, B and NK cells from secondary lymphoid tissue, spleen (S2 Fig), These results showed a significant contribution of SND1 in enhancing Th1/17 cytokine responses of both CD4+ and CD8+ T cells and reducing CD4+Foxp3+ Treg cells during Cm infection.