Our study found that after ENPP1 was inhibited by PC-1 siRNA, the expression of E-cadherin in A2780 and SKOV3 cells was increased, and the expression of N-cadherin and vimentin were both decreased significantly, indicating that the cellular biological process of EMT is involved in the occurrence and development of ovarian cancer cells. The gene discussed is ENPP1; the disease is ovarian cancer.