In addition, comparison of endocrine and metabolic factors between lean and obese women belonging to the same Rotterdam phenotype reveals that majority of insulin, gonadotropin and lipid related factors are worsened by obesity which was largely discerned in phenotypes A and D. All in all, it may seem that obesity may not shape androgen profiles as no significant differences were noted in total, free and bioavailable testosterone levels between lean and obese women belonging to the same phenotype. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.