Increased circulating levels of pro-inflammatory mediators, including highly sensitive C-reactive protein (hsCRP), tumour necrosis factor (TNF)-alpha, procalcitonin and interleukin-18 (IL-18), have been reported in women with PCOS (33, 34), and although more pronounced in the context of obesity, these associations persist even after correction for total fat mass. The gene discussed is CRP; the disease is Obesity.