With regard to pancreatic carcinogenesis, we have reported that cumulative DNA methylation of tumor-related genes, such as BRCA1, APC, CDKN2A, and TIMP3, is associated with overexpression of DNA methyltransferase (DNMT) 1 (Peng et al. 2005), the major DNMT, even in peripheral pancreatic duct epithelia with an inflammatory background (Peng et al. 2006), which may be at the precancerous stage in the context of chronic pancreatitis. The gene discussed is DNMT1; the disease is neoplasm.